{"id":1885,"date":"2025-05-26T18:15:20","date_gmt":"2025-05-26T18:15:20","guid":{"rendered":"https:\/\/lightgreen-wolverine-597643.hostingersite.com\/?page_id=1885"},"modified":"2025-07-05T21:14:35","modified_gmt":"2025-07-05T21:14:35","slug":"research-publications","status":"publish","type":"page","link":"https:\/\/montrealmodelketaminetherapy.com\/fr\/research-publications\/","title":{"rendered":"Publications"},"content":{"rendered":"
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Publications<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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The Montreal Model: An Integrative Biomedical-Psychedelic Approach to Ketamine for Severe Treatment-Resistant Depression.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Cet article d\u00e9crit le d\u00e9veloppement et le protocole du Mod\u00e8le de Montr\u00e9al, ainsi que les connaissances accumul\u00e9es par l'\u00e9quipe au cours de centaines de s\u00e9ances de k\u00e9tamine men\u00e9es aupr\u00e8s de patients tr\u00e8s s\u00e9v\u00e8rement atteints de d\u00e9pression r\u00e9sistante au traitement (DRT). Afin de contextualiser le d\u00e9veloppement du mod\u00e8le, nous examinons les donn\u00e9es probantes sur la k\u00e9tamine comme traitement biom\u00e9dical et psych\u00e9d\u00e9lique de la d\u00e9pression, en soulignant les forces, les faiblesses et les modes d'utilisation distincts de chaque perspective. Cet article d\u00e9taille la justification du mod\u00e8le, ses composantes, les objectifs et les activit\u00e9s de chaque s\u00e9ance, ainsi que les m\u00e9canismes th\u00e9rapeutiques postul\u00e9s.<\/p>

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Garel, N., Drury, J., Thibault L\u00e9vesque, J., Goyette, N., Lehmann, A., Looper, K., Erritzoe, D., Dames, S., Turecki, G., Rej, S., & Greenway, K. T. (2023). The Montreal model: An integrative biomedical-psychedelic approach to ketamine for severe treatment-resistant depression. Frontiers in Psychiatry<\/i>, 14<\/i>, 1268832. https:\/\/doi.org\/10.3389\/fpsyt.2023.1268832<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Essai MUSIK<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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L'essai clinique randomis\u00e9 MUSIK (Musique pour perfusions subanesth\u00e9siques de k\u00e9tamine) a \u00e9t\u00e9 men\u00e9 entre janvier 2021 et ao\u00fbt 2022 \u00e0 Montr\u00e9al, au Canada. Il visait \u00e0 \u00e9valuer les effets de la psychoth\u00e9rapie assist\u00e9e par k\u00e9tamine, avec et sans musique, sur des patients souffrant de d\u00e9pression hautement r\u00e9sistante au traitement (DRT). Au cours de cet essai, six perfusions subanesth\u00e9siques de k\u00e9tamine ont \u00e9t\u00e9 administr\u00e9es sur quatre semaines \u00e0 32 participants, accompagn\u00e9es d'un soutien psychologique structur\u00e9.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Music as an Intervention to Improve the Hemodynamic Response of Ketamine in Depression: A Randomized Clinical Trial.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Cet article pr\u00e9sente le crit\u00e8re d'\u00e9valuation principal de l'essai MUSIK\u00a0: les variations de la pression art\u00e9rielle systolique. Nous avons examin\u00e9 l'impact de la musique sur la r\u00e9ponse h\u00e9modynamique \u00e0 la k\u00e9tamine intraveineuse chez des patients atteints de TRD. Compte tenu de la propension de la k\u00e9tamine \u00e0 \u00e9lever la pression art\u00e9rielle, l'\u00e9tude a \u00e9valu\u00e9 si la musique, en tant qu'intervention non pharmacologique, pouvait moduler ces effets cardiovasculaires. Les participants ont re\u00e7u des perfusions sous-anesth\u00e9siques de k\u00e9tamine, avec ou sans musique, avec surveillance continue de la pression art\u00e9rielle et de la fr\u00e9quence cardiaque. Les r\u00e9sultats ont indiqu\u00e9 que la musique \u00e9tait associ\u00e9e \u00e0 une att\u00e9nuation des augmentations de la pression art\u00e9rielle pendant le traitement, ce qui sugg\u00e8re que la musique pourrait constituer un compl\u00e9ment simple et efficace pour am\u00e9liorer la s\u00e9curit\u00e9 et la tol\u00e9rance de l'administration de k\u00e9tamine en milieu psychiatrique.<\/p>

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Greenway, K. T., Garel, N., Dinh-Williams, A. L., Beaulieu, S., Turecki, G., Rej, S., & Richard-Devantoy, S. (2024). Music as an Intervention to Improve the Hemodynamic Response of Ketamine in Depression: A Randomized Clinical Trial. JAMA Network Open<\/i>, 7<\/i>(2), e2354719. https:\/\/doi.org\/10.1001\/jamanetworkopen.2023.54719<\/a><\/p>

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The Music for Subanesthetic Infusions of Ketamine Randomised Clinical Trial: Ketamine as a Psychedelic Treatment for Highly Refractory Depression.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Cet article pr\u00e9sente les r\u00e9sultats psychiatriques de l'essai MUSIK, globalement et pour les deux groupes\u00a0: troubles musicaux et non musicaux. Les deux groupes de traitement ont montr\u00e9 des am\u00e9liorations substantielles et durables de la d\u00e9pression, de l'anxi\u00e9t\u00e9 et des tendances suicidaires, les effets persistant au moins huit semaines apr\u00e8s le traitement. Il est important de noter que l'intensit\u00e9 des exp\u00e9riences de type mystique pendant les s\u00e9ances, et non la musique elle-m\u00eame, \u00e9tait fortement associ\u00e9e \u00e0 de meilleurs r\u00e9sultats antid\u00e9presseurs. Ces r\u00e9sultats confirment l'efficacit\u00e9 des traitements \u00e0 la k\u00e9tamine de type psych\u00e9d\u00e9lique et soulignent le potentiel th\u00e9rapeutique de l'int\u00e9gration d'\u00e9l\u00e9ments psychologiques et contextuels \u2013 tels que le contexte, le cadre et les soins de soutien \u2013 dans les interventions \u00e0 base de k\u00e9tamine pour la d\u00e9pression s\u00e9v\u00e8re.<\/p>

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Greenway, K. T., Garel, N., Dinh-Williams, L.-A. L., Thibault L\u00e9vesque, J., Kaelen, M., Dagenais-Beaul\u00e9, V., \u2026 Richard-Devantoy, S. (2025). The Music for Subanesthetic Infusions of Ketamine randomised clinical trial: ketamine as a psychedelic treatment for highly refractory depression.\u00a0The British Journal of Psychiatry<\/i>, 1\u20139. doi:10.1192\/bjp.2025.102<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Intravenous Ketamine for Benzodiazepine Deprescription and Withdrawal Management in Treatment-Resistant Depression: A Preliminary Report. <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Cet article examine une \u00e9tude de cohorte ambidirectionnelle que nous avons men\u00e9e aupr\u00e8s de patients participant au Mod\u00e8le de Montr\u00e9al pour la d\u00e9pression et le trouble de stress post-traumatique (TRD) et prenant des benzodiaz\u00e9pines \u00e0 long terme (ou m\u00e9dicaments Z) lors de l'\u00e9valuation. Les participants sous traitement ont \u00e9t\u00e9 \u00e9valu\u00e9s quant \u00e0 leur capacit\u00e9 \u00e0 r\u00e9duire ou \u00e0 cesser leur consommation de benzodiaz\u00e9pines. L'\u00e9tude a r\u00e9v\u00e9l\u00e9 que les perfusions de k\u00e9tamine soulageaient non seulement les sympt\u00f4mes d\u00e9pressifs, mais facilitaient \u00e9galement la diminution progressive et l'arr\u00eat des benzodiaz\u00e9pines chez une proportion significative de patients. Ces r\u00e9sultats sugg\u00e8rent que la k\u00e9tamine pourrait jouer un double r\u00f4le th\u00e9rapeutique dans la prise en charge de la TRD et dans la d\u00e9prescription des benzodiaz\u00e9pines, offrant ainsi une piste prometteuse pour relever les d\u00e9fis de la d\u00e9pendance \u00e0 long terme aux benzodiaz\u00e9pines dans cette population.<\/p>

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Garel, N., Greenway, K. T., L., A., Turecki, G., & Rej, S. (2023). Intravenous ketamine for benzodiazepine deprescription and withdrawal management in treatment-resistant depression: A preliminary report. Neuropsychopharmacology<\/i>, 48<\/i>(12), 1769-1777. https:\/\/doi.org\/10.1038\/s41386-023-01689-y<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Imprinting: Expanding the Extra-Pharmacological Model of Psychedelic Drug Action to Incorporate Delayed Influences of Sets and Settings. <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Cet article introduit le concept d'\u00ab imprinting\u00a0\u00bb afin de d\u00e9crire comment des expositions environnementales r\u00e9centes, notamment num\u00e9riques, peuvent influencer le contenu et la qualit\u00e9 \u00e9motionnelle des exp\u00e9riences psych\u00e9d\u00e9liques, y compris celles induites par la k\u00e9tamine. S'appuyant sur des donn\u00e9es qualitatives issues d'un essai clinique de psychoth\u00e9rapie assist\u00e9e par k\u00e9tamine pour le trouble de la personnalit\u00e9 psych\u00e9d\u00e9lique, plusieurs cas ont r\u00e9v\u00e9l\u00e9 que des images et des th\u00e8mes issus des m\u00e9dias consomm\u00e9s quelques jours avant les s\u00e9ances de traitement r\u00e9apparaissaient sous forme d'hallucinations vives, prenant parfois le pas sur les intentions th\u00e9rapeutiques et r\u00e9duisant la profondeur de l'engagement mystique ou \u00e9motionnel. De plus, une revue approfondie de la litt\u00e9rature a r\u00e9v\u00e9l\u00e9 des exemples pass\u00e9s et m\u00e9connus de ph\u00e9nom\u00e8nes d'imprinting li\u00e9s \u00e0 une grande vari\u00e9t\u00e9 de drogues psych\u00e9d\u00e9liques. Ces r\u00e9sultats \u00e9largissent le mod\u00e8le traditionnel du \u00ab\u00a0set and setting\u00a0\u00bb en int\u00e9grant des influences contextuelles diff\u00e9r\u00e9es, sugg\u00e9rant que les sch\u00e9mas comportementaux avant le traitement, conscients ou inconscients, peuvent influencer significativement les r\u00e9sultats. Le concept d'imprinting offre un cadre utile pour optimiser les th\u00e9rapies psych\u00e9d\u00e9liques gr\u00e2ce \u00e0 une pr\u00e9paration plus intentionnelle et individualis\u00e9e.<\/p>

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Garel, N., Thibault L\u00e9vesque, J., Sandra, D. A., Solomonova, E., Lifshitz, M., & Greenway, K. T. (2023). Imprinting: Expanding the extra-pharmacological model of psychedelic drug action to incorporate delayed influences of sets and settings. Frontiers in Human Neuroscience<\/i>, 17<\/i>, 1200393. https:\/\/doi.org\/10.3389\/fnhum.2023.1200393<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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The Ketamine Chameleon: History, Pharmacology, and the Contested Value of Experience<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Les effets psychoactifs de la k\u00e9tamine ont inspir\u00e9 diverses interpr\u00e9tations. Dans cette revue, nous proposons une analyse approfondie d'une litt\u00e9rature anesth\u00e9sique n\u00e9glig\u00e9e, offrant un angle unique pour mieux comprendre les influences extrapharmacologiques sur les effets subjectifs et th\u00e9rapeutiques de la k\u00e9tamine, notamment la puissance remarquable de la mani\u00e8re dont les effets du m\u00e9dicament sont pr\u00e9sent\u00e9s. Nous retra\u00e7ons l'\u00e9volution historique de ces perspectives \u2013 que nous classons globalement comme \u00ab dissociatives \u00bb, \u00ab oniriques \u00bb et \u00ab psych\u00e9d\u00e9liques \u00bb \u2013 et illustrons leur \u00e9mergence dans ces contextes cliniques. Nous soulignons l'influence de facteurs tels que le langage, la dose et le contexte environnemental sur les effets de la k\u00e9tamine et les r\u00e9sultats th\u00e9rapeutiques. Nous abordons les m\u00e9canismes potentiels sous-jacents \u00e0 ces effets contextuels et explorons leurs ramifications cliniques et scientifiques plus larges.<\/p>

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Diep, D., de la Salle, S., Thibault L\u00e9vesque, J., Lifshitz, M., Garel, N., & Greenway, K. T. (2025). The ketamine chameleon: history, pharmacology, and the contested value of experience.\u00a0Expert review of clinical pharmacology<\/i>,\u00a018<\/i>(3), 109\u2013129. https:\/\/doi.org\/10.1080\/17512433.2025.2459377<\/a><\/p>

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Rapports de cas<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Rapid Improvement of Post-Partum Depression With Subanesthetic Racemic Ketamine<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Guay, \u00c9., Brouillette, M. J., Drury, J., Garel, N., & Greenway, K. (2024). Rapid Improvement of Post-Partum Depression With Subanesthetic Racemic Ketamine.\u00a0Journal of clinical psychopharmacology<\/i>,\u00a044<\/i>(2), 196\u2013198. https:\/\/doi.org\/10.1097\/JCP.0000000000001780<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Ketamine for Depression: A Potential Role in Requests for Medical Aid in Dying?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Garel, N., Nazon, M., Naghi, K., Willis, E., Looper, K., Rej, S., & Greenway, K. T. (2023). Ketamine for depression: a potential role in requests for Medical Aid in Dying?.\u00a0International clinical psychopharmacology<\/i>,\u00a038<\/i>(5), 352\u2013355. https:\/\/doi.org\/10.1097\/YIC.0000000000000462<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Adjunctive Music Improves the Tolerability of Intravenous Ketamine for Bipolar Depression<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Greenway, K. T., Garel, N., Goyette, N., Turecki, G., & Richard-Devantoy, S. (2021). Adjunctive music improves the tolerability of intravenous ketamine for bipolar depression.\u00a0International clinical psychopharmacology<\/i>,\u00a036<\/i>(4), 218\u2013220. https:\/\/doi.org\/10.1097\/YIC.0000000000000363<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"

Research Publications The Montreal Model: An Integrative Biomedical-Psychedelic Approach to Ketamine for Severe Treatment-Resistant Depression. This article outlines the development and protocol of the Montreal Model and the team\u2019s cumulative knowledge gained from hundreds of ketamine sessions conducted with highly severe patients with treatment resistant depression (TRD). To contextualize the model’s development, we review the […]<\/p>","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"full-width-container","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-1885","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/montrealmodelketaminetherapy.com\/fr\/wp-json\/wp\/v2\/pages\/1885","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/montrealmodelketaminetherapy.com\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/montrealmodelketaminetherapy.com\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/montrealmodelketaminetherapy.com\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/montrealmodelketaminetherapy.com\/fr\/wp-json\/wp\/v2\/comments?post=1885"}],"version-history":[{"count":142,"href":"https:\/\/montrealmodelketaminetherapy.com\/fr\/wp-json\/wp\/v2\/pages\/1885\/revisions"}],"predecessor-version":[{"id":2518,"href":"https:\/\/montrealmodelketaminetherapy.com\/fr\/wp-json\/wp\/v2\/pages\/1885\/revisions\/2518"}],"wp:attachment":[{"href":"https:\/\/montrealmodelketaminetherapy.com\/fr\/wp-json\/wp\/v2\/media?parent=1885"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}